The campus at Panangad lies on the western side and eastern side of the National Highway. The total area of this campus is 87.73 acres. It includes the already developed area in which the administrative building, academic block, the quarters, hostels etc are located. Major portion of the campus is occupied by fish ponds and natural mangrove vegetation. The campus is bordered on the western side by the Vemband backwater system.
The North East campus lies on the East side of the National Highway 66 and North side of KUFOS main campus. This campus is occupied by School of Management
Regional Center , Payyannur is the first Regional Center of Kerala University of Fisheries and Ocean Studies (KUFOS) in Payyannur, Kannur was started on 11 October 2018. This Regional Center at Payyannur is expected to focus on various research activities in the area of fishery management. The center will also introduce programmes for the empowerment of fisher folk in South Kerala.